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TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution

Recent evidence has linked the lysosomal cholesterol accumulation in Niemann–Pick type C1 with anomalies associated with primary ciliogenesis. Here, we report that perturbed intracellular cholesterol distribution imposed by lysosomal cholesterol accumulation during TMEM135 depletion is closely assoc...

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Bibliografski detalji
Izdano u:EMBO Rep
Glavni autori: Maharjan, Yunash, Lee, Joon No, Kwak, Seong Ae, Dutta, Raghbendra Kumar, Park, Channy, Choe, Seong‐Kyu, Park, Raekil
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202201/
https://ncbi.nlm.nih.gov/pubmed/32157776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948901
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