TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution

Recent evidence has linked the lysosomal cholesterol accumulation in Niemann–Pick type C1 with anomalies associated with primary ciliogenesis. Here, we report that perturbed intracellular cholesterol distribution imposed by lysosomal cholesterol accumulation during TMEM135 depletion is closely assoc...

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Bibliografiske detaljer
Udgivet i:EMBO Rep
Main Authors: Maharjan, Yunash, Lee, Joon No, Kwak, Seong Ae, Dutta, Raghbendra Kumar, Park, Channy, Choe, Seong‐Kyu, Park, Raekil
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202201/
https://ncbi.nlm.nih.gov/pubmed/32157776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948901
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