Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1

Mitochondrial function depends crucially on the maintenance of multiple mitochondrial DNA (mtDNA) copies. Surprisingly, the cellular mechanisms regulating mtDNA copy number remain poorly understood. Through a systematic high-throughput approach in Saccharomyces cerevisiae, we determined mtDNA–to–nuc...

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Publicat a:Mol Biol Cell
Autors principals: Göke, Aylin, Schrott, Simon, Mizrak, Arda, Belyy, Vladislav, Osman, Christof, Walter, Peter
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202074/
https://ncbi.nlm.nih.gov/pubmed/31532710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-08-0470
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