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Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1

Mitochondrial function depends crucially on the maintenance of multiple mitochondrial DNA (mtDNA) copies. Surprisingly, the cellular mechanisms regulating mtDNA copy number remain poorly understood. Through a systematic high-throughput approach in Saccharomyces cerevisiae, we determined mtDNA–to–nuc...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Göke, Aylin, Schrott, Simon, Mizrak, Arda, Belyy, Vladislav, Osman, Christof, Walter, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202074/
https://ncbi.nlm.nih.gov/pubmed/31532710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-08-0470
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