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Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1

Mitochondrial function depends crucially on the maintenance of multiple mitochondrial DNA (mtDNA) copies. Surprisingly, the cellular mechanisms regulating mtDNA copy number remain poorly understood. Through a systematic high-throughput approach in Saccharomyces cerevisiae, we determined mtDNA–to–nuc...

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Pubblicato in:Mol Biol Cell
Autori principali: Göke, Aylin, Schrott, Simon, Mizrak, Arda, Belyy, Vladislav, Osman, Christof, Walter, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202074/
https://ncbi.nlm.nih.gov/pubmed/31532710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-08-0470
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