Brd4 and P300 confer transcriptional competency during zygotic genome activation

The awakening of the genome after fertilization is a cornerstone of animal development. However, the mechanisms that activate the silent genome after fertilization are poorly understood. Here, we show that transcriptional competency is regulated by Brd4 and p300-dependent histone acetylation in zebr...

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Udgivet i:Dev Cell
Main Authors: Chan, Shun Hang, Tang, Yin, Miao, Liyun, Darwich-Codore, Hiba, Vejnar, Charles E., Beaudoin, Jean-Denis, Musaev, Damir, Fernandez, Juan P., Benitez, Maria D.J., Bazzini, Ariel A., Moreno-Mateos, Miguel A., Giraldez, Antonio J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201981/
https://ncbi.nlm.nih.gov/pubmed/31211993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.05.037
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