In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

BACKGROUND: In utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term molecular changes that predispose mammary cells to carcinogenic transformation are unknown. Herein, we investigated how endocrine di...

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Pubblicato in:Breast Cancer Res
Autori principali: Wormsbaecher, Clarissa, Hindman, Andrea R., Avendano, Alex, Cortes-Medina, Marcos, Jones, Caitlin E., Bushman, Andrew, Onua, Lotanna, Kovalchin, Claire E., Murphy, Alina R., Helber, Hannah L., Shapiro, Ali, Voytovitch, Kyle, Kuang, Xingyan, Aguilar-Valenzuela, Renan, Leight, Jennifer L., Song, Jonathan W., Burd, Craig J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201668/
https://ncbi.nlm.nih.gov/pubmed/32370801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-01275-w
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