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Synthesis and Reactions of 3,3-Difluoro-2-exo-methylidene Indolines

[Image: see text] A dearomative electrophilic fluorination of 2-methylindoles is reported, delivering 3,3-difluoroindolines bearing an exomethylidene. The model substrate was synthesized on up to a 20 mmol scale and was purified by a practical recrystallization as a crystalline bench-stable, yet rea...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Org Lett
Prif Awduron: Zeidan, Nicolas, Zambri, Matthew, Unger, Sven, Dank, Christian, Torelli, Alexa, Mirabi, Bijan, Lautens, Mark
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2020
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201399/
https://ncbi.nlm.nih.gov/pubmed/32276536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c01175
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