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A high-resolution description of β(1)-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by extra- and intracellular ligands occurs via modulation of complex conformational equilibria, but their exact kinetic details and underlying atomic mechanisms are unknown. Here we quantified these dynamic equilibria in the β...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7200737/ https://ncbi.nlm.nih.gov/pubmed/32371991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15864-y |
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