Human host defense peptide LL-37 facilitates double-stranded RNA pro-inflammatory signaling through up-regulation of TLR3 expression in vascular smooth muscle cells

OBJECTIVE: The importance of human host defense peptide LL-37 in vascular innate immunity is not understood. Here, we assess the impact of LL-37 on double-stranded RNA (dsRNA) signaling in human vascular smooth muscle cells. MATERIALS AND METHODS: Cellular import of LL-37 and synthetic dsRNA (poly I...

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Vydáno v:Inflamm Res
Hlavní autoři: Dahl, Sara, Cerps, Samuel, Rippe, Catarina, Swärd, Karl, Uller, Lena, Svensson, Daniel, Nilsson, Bengt-Olof
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
Témata:
Original Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200649/
https://ncbi.nlm.nih.gov/pubmed/32221618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00011-020-01340-2
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