Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

In Wnt/β-catenin signaling, the transcriptional coactivator β-catenin is regulated by its phosphorylation in a complex that includes the scaffold protein Axin and associated kinases. Wnt binding to its coreceptors activates the cytosolic effector Dishevelled (Dvl), leading to the recruitment of Axin...

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Publicado en:eLife
Autores principales: Kan, Wei, Enos, Michael D, Korkmazhan, Elgin, Muennich, Stefan, Chen, Dong-Hua, Gammons, Melissa V, Vasishtha, Mansi, Bienz, Mariann, Dunn, Alexander R, Skiniotis, Georgios, Weis, William I
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200158/
https://ncbi.nlm.nih.gov/pubmed/32297861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55015
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