The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. APC downregulates Wnt signalling by enabling Axin to promote the degradation of the Wnt signalling effector β-catenin (Armadillo in flies). This depends on Axin's DIX...

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Detalles Bibliográficos
Autores principales: Mendoza-Topaz, Carolina, Mieszczanek, Juliusz, Bienz, Mariann
Formato: Artigo
Lenguaje:Inglês
Publicado: The Royal Society 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352083/
https://ncbi.nlm.nih.gov/pubmed/22645652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.110013
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