The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. APC downregulates Wnt signalling by enabling Axin to promote the degradation of the Wnt signalling effector β-catenin (Armadillo in flies). This depends on Axin's DIX...

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Bibliografiska uppgifter
Huvudupphovsmän: Mendoza-Topaz, Carolina, Mieszczanek, Juliusz, Bienz, Mariann
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Royal Society 2011
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352083/
https://ncbi.nlm.nih.gov/pubmed/22645652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.110013
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