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Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes

A single particle cryo-EM reconstruction of an ∼160-kD N-terminal fragment of the lipid transport protein VPS13 reveals an ∼160-Å long channel lined with hydrophobic residues suitable for solubilizing multiple lipid fatty acid moieties. The structure suggests that VPS13 and related proteins, like th...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Li, PeiQi, Lees, Joshua Aaron, Lusk, C. Patrick, Reinisch, Karin M.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199853/
https://ncbi.nlm.nih.gov/pubmed/32182622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202001161
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