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Mitotic stress-induced secretome primes cancer cells to apoptosis and maximizes paclitaxel response in breast tumors when combined with BCL-xL-targeting BH3 mimetics

We recently identified a previously unappreciated ability of antimitotics to propagate apoptotic priming across cancer cell populations. The underlying paracrine cytotoxic signal, fueled by undead cells activating the cGAS/STING pathway, is required for in vivo antitumor response and it can be furth...

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Bibliografiske detaljer
Udgivet i:Mol Cell Oncol
Main Authors: Lohard, Steven, Juin, Philippe P., Barillé-Nion, Sophie
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199744/
https://ncbi.nlm.nih.gov/pubmed/32391429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1735912
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