Amide-Containing α-Hydroxytropolones as Inhibitors of Hepatitis B Virus Replication

The Hepatitis B Virus (HBV) ribonuclease H (RNaseH) is a promising but unexploited drug target. Here, we synthesized and analyzed a library of 57 amide-containing α-hydroxytropolones (αHTs) as potential leads for HBV drug development. Fifty percent effective concentrations ranged from 0.31 to 54 μM,...

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Bibliographic Details
Published in:Antiviral Res
Main Authors: Li, Qilan, Lomonosova, Elena, Donlin, Maureen J., Cao, Feng, O’Dea, Austin, Milleson, Brienna, Berkowitz, Alex J., Baucom, John-Charles, Stasiak, John P., Schiavone, Daniel V., Abdelmessih, Rudolf G., Lyubimova, Anastasiya, Fraboni, Americo J., Bejcek, Lauren P., Villa, Juan A., Gallicchio, Emilio, Murelli, Ryan P., Tavis, John E.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199283/
https://ncbi.nlm.nih.gov/pubmed/32217151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2020.104777
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