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Unlocking the door for ERAD

Misfolded proteins in the endoplasmic reticulum (ER) are returned to the cytosol and destroyed by a process known as ER-associated degradation (ERAD). Hrd1 has been implicated as the channel that mediates the transport of ERAD substrates to the cytosol. A study demonstrates that Hrd1 is gated by aut...

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Publicat a:Nat Cell Biol
Autors principals: Betegon, Miguel, Brodsky, Jeffrey L.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199279/
https://ncbi.nlm.nih.gov/pubmed/32103187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0476-1
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