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Unlocking the door for ERAD
Misfolded proteins in the endoplasmic reticulum (ER) are returned to the cytosol and destroyed by a process known as ER-associated degradation (ERAD). Hrd1 has been implicated as the channel that mediates the transport of ERAD substrates to the cytosol. A study demonstrates that Hrd1 is gated by aut...
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| Опубликовано в: : | Nat Cell Biol |
|---|---|
| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7199279/ https://ncbi.nlm.nih.gov/pubmed/32103187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0476-1 |
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