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Unlocking the door for ERAD

Misfolded proteins in the endoplasmic reticulum (ER) are returned to the cytosol and destroyed by a process known as ER-associated degradation (ERAD). Hrd1 has been implicated as the channel that mediates the transport of ERAD substrates to the cytosol. A study demonstrates that Hrd1 is gated by aut...

詳細記述

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書誌詳細
出版年:Nat Cell Biol
主要な著者: Betegon, Miguel, Brodsky, Jeffrey L.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199279/
https://ncbi.nlm.nih.gov/pubmed/32103187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0476-1
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