RNA-Seq-Based TCR Profiling Reveals Persistently Increased Intratumoral Clonality in Responders to Anti-PD-1 Therapy

Substantial effort is being invested in the search for peripheral or intratumoral T cell receptor (TCR) repertoire features that could predict the response to immunotherapy. Here we demonstrate the utility of MiXCR software for TCR and immunoglobulin repertoire extraction from RNA-Seq data obtained...

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Vydáno v:Front Oncol
Hlavní autoři: Zhigalova, Ekaterina A., Izosimova, Anna I., Yuzhakova, Diana V., Volchkova, Lilia N., Shagina, Irina A., Turchaninova, Maria A., Serebrovskaya, Ekaterina O., Zagaynova, Elena V., Chudakov, Dmitriy M., Sharonov, George V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199218/
https://ncbi.nlm.nih.gov/pubmed/32411589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00385
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