Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA

IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement of Aurora B activity at the interphase. Here, we demonstrate that IK, a spliceosomal component, plays a crucial role in the proper splicing of the ATM pre-mRNA among other genes related with t...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Ka, Hye In, Lee, Sunyi, Han, Sora, Jeong, Ae Lee, Park, Ji Young, Joo, Hyun Jeong, Soh, Su Jung, Park, Doyeon, Yang, Young
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198525/
https://ncbi.nlm.nih.gov/pubmed/32377397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0268-1
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