Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease

BACKGROUND & AIMS: Celiac disease could be treated, and potentially cured, by restoring T-cell tolerance to gliadin. We investigated the safety and efficacy of negatively charged, 500 nm, poly(lactide-co-glycolide) nanoparticles encapsulating gliadin protein (TIMP-GLIA) in 3 mouse models of celi...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Freitag, Tobias L., Podojil, Joseph R., Pearson, Ryan M., Fokta, Frank J., Sahl, Cecilia, Messing, Marcel, Andersson, Leif C., Leskinen, Katarzyna, Saavalainen, Päivi, Hoover, Lisa I., Huang, Kelly, Phippard, Deborah, Maleki, Sanaz, King, Nicholas J.C., Shea, Lonnie D., Miller, Stephen D., Meri, Seppo K., Getts, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198359/
https://ncbi.nlm.nih.gov/pubmed/32032584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.01.045
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