Secretion of celiac disease autoantibodies after in vitro gliadin challenge is dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits

BACKGROUND: In celiac disease gluten, the disease-inducing toxic component in wheat, induces the secretion of autoantibodies which are targeted against transglutaminase 2 (TG2). These autoantibodies are produced in the small-intestinal mucosa, where they can be found deposited extracellularly below...

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Detalhes bibliográficos
Main Authors: Stenman, Satumarja M, Lindfors, Katri, Korponay-Szabo, Ilma R, Lohi, Olli, Saavalainen, Päivi, Partanen, Jukka, Haimila, Katri, Wieser, Herbert, Mäki, Markku, Kaukinen, Katri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275217/
https://ncbi.nlm.nih.gov/pubmed/18312620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-9-6
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