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Opposing patterns of abnormal D1 and D2 receptor dependent cortico-striatal plasticity explain increased risk taking in patients with DYT1 dystonia

Patients with DYT1 dystonia caused by the mutated TOR1A gene exhibit risk neutral behaviour compared to controls who are risk averse in the same reinforcement learning task. It is unclear whether this behaviour can be linked to changes in cortico-striatal plasticity demonstrated in animal models whi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gilbertson, Tom, Arkadir, David, Steele, J. Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197855/
https://ncbi.nlm.nih.gov/pubmed/32365120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226790
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