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Leveraging mouse chromatin data for heritability enrichment informs common disease architecture and reveals cortical layer contributions to schizophrenia

Genome-wide association studies have implicated thousands of noncoding variants across common human phenotypes. However, they cannot directly inform the cellular context in which disease-associated variants act. Here, we use open chromatin profiles from discrete mouse cell populations to address thi...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Hook, Paul W., McCallion, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197474/
https://ncbi.nlm.nih.gov/pubmed/32303558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.256578.119
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