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Autophagy promotes mammalian survival by suppressing oxidative stress and p53
Autophagy captures intracellular components and delivers them to lysosomes for degradation and recycling. Conditional autophagy deficiency in adult mice causes liver damage, shortens life span to 3 mo due to neurodegeneration, and is lethal upon fasting. As autophagy deficiency causes p53 induction...
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| Udgivet i: | Genes Dev |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7197357/ https://ncbi.nlm.nih.gov/pubmed/32193353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.335570.119 |
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