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Zinc promotes liquid–liquid phase separation of tau protein

Tau is a microtubule-associated protein that plays a major role in Alzheimer's disease (AD) and other tauopathies. Recent reports indicate that, in the presence of crowding agents, tau can undergo liquid–liquid phase separation (LLPS), forming highly dynamic liquid droplets. Here, using recombi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Singh, Virender, Xu, Ling, Boyko, Solomiia, Surewicz, Krystyna, Surewicz, Witold K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196643/
https://ncbi.nlm.nih.gov/pubmed/32229582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC120.013166
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