Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism

The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs/ADGRLs) promotes excitatory synapse formation when LPHNs simultaneously interact with FLRTs. Insertion of a short alternatively-spliced region within TENs abolishes the TEN-LPHN interaction and sw...

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Udgivet i:Nat Commun
Main Authors: Li, Jingxian, Xie, Yuan, Cornelius, Shaleeka, Jiang, Xian, Sando, Richard, Kordon, Szymon P., Pan, Man, Leon, Katherine, Südhof, Thomas C., Zhao, Minglei, Araç, Demet
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195488/
https://ncbi.nlm.nih.gov/pubmed/32358586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16029-7
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