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Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

Bidirectional signaling by cell-adhesion molecules is thought to mediate synapse formation, but the mechanisms involved remain elusive. Here we found that the adhesion-G-protein-coupled receptors latrophilin-2 and latrophilin-3 selectively directed formation of perforant-path and Schaffer-collateral...

詳細記述

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書誌詳細
出版年:Science
主要な著者: Sando, Richard, Jiang, Xian, Südhof, Thomas C.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636343/
https://ncbi.nlm.nih.gov/pubmed/30792275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7969
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