Structural basis for teneurin function in circuit-wiring: A toxin motif at the synapse

Teneurins (TENs) are cell-surface adhesion proteins with critical roles in tissue development and axon guidance. Here we report the 3.1-Å electron cryo-microscopy structure of the human TEN2 extracellular region (ECR), revealing a striking similarity to bacterial Tc-toxins. The ECR includes a large...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Li, Jingxian, Shalev-Benami, Moran, Sando, Richard, Jiang, Xian, Kibrom, Amanuel, Wang, Jie, Leon, Katherine, Katanski, Christopher, Nazarko, Olha, Lu, Yue C., Südhof, Thomas C., Skiniotis, Georgios, Araç, Demet
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912346/
https://ncbi.nlm.nih.gov/pubmed/29677516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.036
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