Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

Mitochondria contribute to shape intraneuronal Ca(2+) signals. Excessive Ca(2+) taken up by mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca(2+) overload, but the effects of Aβ on mitochondrial Ca(2+) levels in Alzheimer’s disease (AD) remain unclear. Using a ratiometric...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Calvo-Rodriguez, Maria, Hou, Steven S., Snyder, Austin C., Kharitonova, Elizabeth K., Russ, Alyssa N., Das, Sudeshna, Fan, Zhanyun, Muzikansky, Alona, Garcia-Alloza, Monica, Serrano-Pozo, Alberto, Hudry, Eloise, Bacskai, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195480/
https://ncbi.nlm.nih.gov/pubmed/32358564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16074-2
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