Mutational signatures are jointly shaped by DNA damage and repair

Cells possess an armamentarium of DNA repair pathways to counter DNA damage and prevent mutation. Here we use C. elegans whole genome sequencing to systematically quantify the contributions of these factors to mutational signatures. We analyse 2,717 genomes from wild-type and 53 DNA repair defective...

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Udgivet i:Nat Commun
Main Authors: Volkova, Nadezda V., Meier, Bettina, González-Huici, Víctor, Bertolini, Simone, Gonzalez, Santiago, Vöhringer, Harald, Abascal, Federico, Martincorena, Iñigo, Campbell, Peter J., Gartner, Anton, Gerstung, Moritz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195458/
https://ncbi.nlm.nih.gov/pubmed/32358516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15912-7
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