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Quantitating Endosomal Escape of a Library of Polymers for mRNA Delivery

Endosomal escape is a key step for intracellular drug delivery of nucleic acids, but reliable and sensitive methods for its quantitation remain an unmet need. In order to rationally optimize the mRNA transfection efficiency of a library of polymeric materials, we designed a deactivated Renilla lucif...

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Detalhes bibliográficos
Publicado no:Nano Lett
Main Authors: Jiang, Yuhang, Lu, Qiao, Wang, Yongheng, Xu, Emily, Ho, Alison, Singh, Priya, Wang, Yifei, Jiang, Zhaozhong, Yang, Fan, Tietjen, Gregory T., Cresswell, Peter, Saltzman, W. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195212/
https://ncbi.nlm.nih.gov/pubmed/32003222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.9b04426
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