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Natural variability in seizure frequency: implications for trials and placebo

BACKGROUND: Changes in patient-reported seizure frequencies are the gold standard used to test efficacy of new treatments in randomized controlled trials (RCTs). Recent analyses of patient seizure diary data suggest that the placebo response may be attributable to natural fluctuations in seizure fre...

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Bibliografske podrobnosti
izdano v:Epilepsy Res
Main Authors: Romero, Juan, Larimer, Phil, Chang, Bernard, Goldenholz, Shira R, Goldenholz, Daniel M
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7194486/
https://ncbi.nlm.nih.gov/pubmed/32172145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2020.106306
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