Does accounting for seizure frequency variability increase clinical trial power?

OBJECTIVE: Seizure frequency variability is associated with placebo responses in randomized controlled trials (RCT). Increased variability can result in drug misclassification and, hence, decreased statistical power. We investigated a new method that directly incorporated variability into RCT analys...

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Pubblicato in:Epilepsy Res
Autori principali: Goldenholz, Daniel M, Goldenholz, Shira R., Moss, Robert, French, Jacqueline, Lowenstein, Daniel, Kuzniecky, Ruben, Haut, Sheryl, Cristofaro, Sabrina, Detyniecki, Kamil, Hixson, John, Karoly, Philippa, Cook, Mark, Strashny, Alex, Theodore, William H, Pieper, Carl
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650933/
https://ncbi.nlm.nih.gov/pubmed/28781216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2017.07.013
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