Does accounting for seizure frequency variability increase clinical trial power?

OBJECTIVE: Seizure frequency variability is associated with placebo responses in randomized controlled trials (RCT). Increased variability can result in drug misclassification and, hence, decreased statistical power. We investigated a new method that directly incorporated variability into RCT analys...

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Bibliografske podrobnosti
izdano v:Epilepsy Res
Main Authors: Goldenholz, Daniel M, Goldenholz, Shira R., Moss, Robert, French, Jacqueline, Lowenstein, Daniel, Kuzniecky, Ruben, Haut, Sheryl, Cristofaro, Sabrina, Detyniecki, Kamil, Hixson, John, Karoly, Philippa, Cook, Mark, Strashny, Alex, Theodore, William H, Pieper, Carl
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650933/
https://ncbi.nlm.nih.gov/pubmed/28781216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2017.07.013
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