Does accounting for seizure frequency variability increase clinical trial power?

OBJECTIVE: Seizure frequency variability is associated with placebo responses in randomized controlled trials (RCT). Increased variability can result in drug misclassification and, hence, decreased statistical power. We investigated a new method that directly incorporated variability into RCT analys...

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Detalhes bibliográficos
Publicado no:Epilepsy Res
Main Authors: Goldenholz, Daniel M, Goldenholz, Shira R., Moss, Robert, French, Jacqueline, Lowenstein, Daniel, Kuzniecky, Ruben, Haut, Sheryl, Cristofaro, Sabrina, Detyniecki, Kamil, Hixson, John, Karoly, Philippa, Cook, Mark, Strashny, Alex, Theodore, William H, Pieper, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650933/
https://ncbi.nlm.nih.gov/pubmed/28781216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2017.07.013
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