Does accounting for seizure frequency variability increase clinical trial power?

OBJECTIVE: Seizure frequency variability is associated with placebo responses in randomized controlled trials (RCT). Increased variability can result in drug misclassification and, hence, decreased statistical power. We investigated a new method that directly incorporated variability into RCT analys...

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Bibliografski detalji
Izdano u:Epilepsy Res
Glavni autori: Goldenholz, Daniel M, Goldenholz, Shira R., Moss, Robert, French, Jacqueline, Lowenstein, Daniel, Kuzniecky, Ruben, Haut, Sheryl, Cristofaro, Sabrina, Detyniecki, Kamil, Hixson, John, Karoly, Philippa, Cook, Mark, Strashny, Alex, Theodore, William H, Pieper, Carl
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650933/
https://ncbi.nlm.nih.gov/pubmed/28781216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2017.07.013
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