Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression

The immunosuppressive tumor microenvironment (TME) is a major barrier to immunotherapy. Within solid tumors, why monocytes preferentially differentiate into immunosuppressive tumor-associated macrophages (TAMs) rather than immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murin...

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Pubblicato in:Cell
Autori principali: Devalaraja, Samir, Jerrick To, Tsun Ki, Folkert, Ian W., Natesan, Ramakrishnan, Alam, Md Zahidul, Li, Minghong, Tada, Yuma, Budagyan, Konstantin, Dang, Mai T., Zhai, Li, Lobel, Graham P., Ciotti, Gabrielle E., Eisinger-Mathason, T.S. Karin, Asangani, Irfan A., Weber, Kristy, Simon, M. Celeste, Haldar, Malay
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7194250/
https://ncbi.nlm.nih.gov/pubmed/32169218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.02.042
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