Necrostatin-1 Ameliorates Neutrophilic Inflammation in Asthma by Suppressing MLKL Phosphorylation to Inhibiting NETs Release

Neutrophilic inflammation occurs during asthma exacerbation, and especially, in patients with steroid-refractory asthma, but the underlying mechanisms are poorly understood. Recently, a significant accumulation of neutrophil extracellular traps (NETs) in the airways of neutrophilic asthma has been d...

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Vydáno v:Front Immunol
Hlavní autoři: Han, X. A., Jie, H. Y., Wang, J. H., Zhang, X. M., Wang, Jun, Yu, C. X., Zhang, J. L., He, J., Chen, J. Q., Lai, K. F., Sun, E. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7194114/
https://ncbi.nlm.nih.gov/pubmed/32391007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00666
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