Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription

To identify genomic alterations contributing to the pathogenesis of high-risk chronic lymphocytic leukemia (CLL) beyond the well-established role of TP53 aberrations, we comprehensively analyzed 75 relapsed/refractory and 71 treatment-naïve high-risk cases from prospective clinical trials by single...

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Pubblicato in:Haematologica
Autori principali: Edelmann, Jennifer, Holzmann, Karlheinz, Tausch, Eugen, Saunderson, Emily A., Jebaraj, Billy M. C., Steinbrecher, Daniela, Dolnik, Anna, Blätte, Tamara J., Landau, Dan A., Saub, Jenny, Estenfelder, Sven, Ibach, Stefan, Cymbalista, Florence, Leblond, Veronique, Delmer, Alain, Bahlo, Jasmin, Robrecht, Sandra, Fischer, Kirsten, Goede, Valentin, Bullinger, Lars, Wu, Catherine J., Mertens, Daniel, Ficz, Gabriella, Gribben, John G., Hallek, Michael, Döhner, Hartmut, Stilgenbauer, Stephan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193490/
https://ncbi.nlm.nih.gov/pubmed/31467127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.217307
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