Lamin B1 regulates somatic mutations and progression of B-cell malignancies

Somatic hypermutation (SHM) is a pivotal process in adaptive immunity that occurs in the germinal centre and allows B cells to change their primary DNA sequence and diversify their antigen receptors. Here, we report that genome binding of Lamin B1, a component of the nuclear envelope involved in epi...

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Détails bibliographiques
Publié dans:Leukemia
Auteurs principaux: Klymenko, T, Bloehdorn, J, Bahlo, J, Robrecht, S, Akylzhanova, G, Cox, K, Estenfelder, S, Wang, J, Edelmann, J, Strefford, J C, Wojdacz, T K, Fischer, K, Hallek, M, Stilgenbauer, S, Cragg, M, Gribben, J, Braun, A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2018
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808072/
https://ncbi.nlm.nih.gov/pubmed/28804121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.255
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