Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice

Conjugation of antisense oligonucleotide (ASO) with a variety of distinct lipophilic moieties like fatty acids and cholesterol increases ASO accumulation and activity in multiple tissues. While lipid conjugation increases tissue exposure in mice and reduces excretion of ASO in urine, histological re...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192618/
https://ncbi.nlm.nih.gov/pubmed/32182359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa164
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