4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration

To address the need for more meaningful biomarkers of tauopathies, we have developed an ultrasensitive tau seed amplification assay (4R RT-QuIC) for the 4-repeat (4R) tau aggregates of progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and other diseases with 4R tauopathy. The as...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: Saijo, Eri, Metrick, Michael A., Koga, Shunsuke, Parchi, Piero, Litvan, Irene, Spina, Salvatore, Boxer, Adam, Rojas, Julio C., Galasko, Douglas, Kraus, Allison, Rossi, Marcello, Newell, Kathy, Zanusso, Gianluigi, Grinberg, Lea T., Seeley, William W., Ghetti, Bernardino, Dickson, Dennis W., Caughey, Byron
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192393/
https://ncbi.nlm.nih.gov/pubmed/31616982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02080-2
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