4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration

To address the need for more meaningful biomarkers of tauopathies, we have developed an ultrasensitive tau seed amplification assay (4R RT-QuIC) for the 4-repeat (4R) tau aggregates of progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and other diseases with 4R tauopathy. The as...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Saijo, Eri, Metrick, Michael A., Koga, Shunsuke, Parchi, Piero, Litvan, Irene, Spina, Salvatore, Boxer, Adam, Rojas, Julio C., Galasko, Douglas, Kraus, Allison, Rossi, Marcello, Newell, Kathy, Zanusso, Gianluigi, Grinberg, Lea T., Seeley, William W., Ghetti, Bernardino, Dickson, Dennis W., Caughey, Byron
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192393/
https://ncbi.nlm.nih.gov/pubmed/31616982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02080-2
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