Oxaliplatin-DNA Adducts as Predictive Biomarkers of FOLFOX Response in Colorectal Cancer: A Potential Treatment Optimization Strategy

FOLFOX is one of the most effective treatments for advanced colorectal cancer (CRC). However, cumulative oxaliplatin neurotoxicity often results in halting the therapy. Oxaliplatin functions predominantly via the formation of toxic covalent drug-DNA adducts. We hypothesize that oxaliplatin-DNA adduc...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Zimmermann, Maike, Li, Tao, Semrad, Thomas J., Wu, Chun-Yi, Yu, Aiming, Cimino, George, Malfatti, Michael, Haack, Kurt, Turteltaub, Kenneth W., Pan, Chong-xian, Cho, May, Kim, Edward J., Henderson, Paul T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192311/
https://ncbi.nlm.nih.gov/pubmed/32029633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0133
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