Repeated Administration of High Dose Depot Medroxy Progesterone Acetate does not Alter SHIV(SF162p3) Viral Kinetics and Tenofovir Pharmacokinetics when Delivered via Intravaginal Rings

BACKGROUND: Intravaginal rings (IVR) for HIV prevention will likely be used by women on depot medroxy progesterone acetate (DMPA) hormonal contraception. We used pigtailed macaques to evaluate the effects of DMPA on tenofovir disoproxil fumarate (TDF) IVR pharmacokinetics and viral shedding. METHODS...

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Bibliografiska uppgifter
I publikationen:J Med Primatol
Huvudupphovsmän: Srinivasan, Priya, Zhang, Jining, Dinh, Chuong T., Teller, Ryan S., McNicholl, Janet M., Kiser, Patrick F., Herold, Betsy C., Smith, James M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192064/
https://ncbi.nlm.nih.gov/pubmed/28748662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jmp.12299
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