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Towards Understanding Region-Specificity of Triplet Repeat Diseases: Coupled Immunohistology and Mass Spectrometry Imaging

Many trinucleotide repeat disorders exhibit region-specific toxicity within tissues, the basis of which cannot be explained by traditional methods. For example, in HD, the toxic disease-causing protein is ubiquitously expressed. However, only the medium spiny neurons in the striatum are initially ta...

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發表在:Methods Mol Biol
Main Authors: Platt, Virginia, Lee, Do Yup, Canaria, Christie, Frankel, Ken, Bernstein, Susan, McMurray, Cynthia
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191641/
https://ncbi.nlm.nih.gov/pubmed/23754228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-62703-411-1_14
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