Effects of Different Doses of GEN-003, a Therapeutic Vaccine for Genital Herpes Simplex Virus-2, on Viral Shedding and Lesions: Results of a Randomized Placebo-Controlled Trial

BACKGROUND: GEN-003 is a candidate therapeutic vaccine for genital herpes simplex virus type 2 (HSV-2). We compared virologic and clinical impact of varying GEN-003 doses. METHODS: Adults with symptomatic HSV-2 received placebo or GEN-003 (30 or 60 µg antigen with 25, 50, or 75 µg adjuvant). Viral s...

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Detalles Bibliográficos
Publicado en:J Infect Dis
Main Authors: Van Wagoner, Nicholas, Fife, Kenneth, Leone, Peter A, Bernstein, David I, Warren, Terri, Panther, Lori, Novak, Richard M, Beigi, Richard, Kriesel, John, Tyring, Stephen, Koltun, William, Lucksinger, Gregg, Morris, Amy, Zhang, Bin, McNeil, Lisa K, Tasker, Sybil, Hetherington, Seth, Wald, Anna
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191615/
https://ncbi.nlm.nih.gov/pubmed/29982727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy415
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