Effects of Different Doses of GEN-003, a Therapeutic Vaccine for Genital Herpes Simplex Virus-2, on Viral Shedding and Lesions: Results of a Randomized Placebo-Controlled Trial

BACKGROUND: GEN-003 is a candidate therapeutic vaccine for genital herpes simplex virus type 2 (HSV-2). We compared virologic and clinical impact of varying GEN-003 doses. METHODS: Adults with symptomatic HSV-2 received placebo or GEN-003 (30 or 60 µg antigen with 25, 50, or 75 µg adjuvant). Viral s...

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Vydáno v:J Infect Dis
Hlavní autoři: Van Wagoner, Nicholas, Fife, Kenneth, Leone, Peter A, Bernstein, David I, Warren, Terri, Panther, Lori, Novak, Richard M, Beigi, Richard, Kriesel, John, Tyring, Stephen, Koltun, William, Lucksinger, Gregg, Morris, Amy, Zhang, Bin, McNeil, Lisa K, Tasker, Sybil, Hetherington, Seth, Wald, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191615/
https://ncbi.nlm.nih.gov/pubmed/29982727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy415
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