Effects of Different Doses of GEN-003, a Therapeutic Vaccine for Genital Herpes Simplex Virus-2, on Viral Shedding and Lesions: Results of a Randomized Placebo-Controlled Trial

BACKGROUND: GEN-003 is a candidate therapeutic vaccine for genital herpes simplex virus type 2 (HSV-2). We compared virologic and clinical impact of varying GEN-003 doses. METHODS: Adults with symptomatic HSV-2 received placebo or GEN-003 (30 or 60 µg antigen with 25, 50, or 75 µg adjuvant). Viral s...

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Dades bibliogràfiques
Publicat a:J Infect Dis
Autors principals: Van Wagoner, Nicholas, Fife, Kenneth, Leone, Peter A, Bernstein, David I, Warren, Terri, Panther, Lori, Novak, Richard M, Beigi, Richard, Kriesel, John, Tyring, Stephen, Koltun, William, Lucksinger, Gregg, Morris, Amy, Zhang, Bin, McNeil, Lisa K, Tasker, Sybil, Hetherington, Seth, Wald, Anna
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191615/
https://ncbi.nlm.nih.gov/pubmed/29982727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy415
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