Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs

Newborn pigs with chronic hypoxia-induced pulmonary hypertension (PH) have evidence of endothelial nitric oxide synthase (eNOS) uncoupling. In this model, we showed that therapies that promote eNOS coupling, either tetrahydrobiopterin (BH(4)), a NOS cofactor, or l-citrulline, a NO-l-arginine precurs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Lung Cell Mol Physiol
Prif Awduron: Dikalova, Anna, Aschner, Judy L., Kaplowitz, Mark R., Cunningham, Gary, Summar, Marshall, Fike, Candice D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191483/
https://ncbi.nlm.nih.gov/pubmed/32073878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00280.2019
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