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Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs
Newborn pigs with chronic hypoxia-induced pulmonary hypertension (PH) have evidence of endothelial nitric oxide synthase (eNOS) uncoupling. In this model, we showed that therapies that promote eNOS coupling, either tetrahydrobiopterin (BH(4)), a NOS cofactor, or l-citrulline, a NO-l-arginine precurs...
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| Publicado no: | Am J Physiol Lung Cell Mol Physiol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7191483/ https://ncbi.nlm.nih.gov/pubmed/32073878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00280.2019 |
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