MetAP2 inhibitor treatment of high-fat and -fructose-fed dogs: impact on the response to oral glucose ingestion and a hyperinsulinemic hyperglycemic clamp

We examined the methionine aminopeptidase 2 inhibitor fumagillin in dogs consuming a high-fat and -fructose diet (HFFD). In pilot studies (3 dogs that had consumed HFFD for 3 yr), 8 wk of daily treatment with fumagillin reduced food intake 29%, weight 6%, and the glycemic excursion during an oral gl...

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Detalhes bibliográficos
Publicado no:Am J Physiol Endocrinol Metab
Main Authors: Moore, Mary Courtney, Coate, Katie C., Scott, Melanie, Kraft, Guillaume, Vath, James E., Hughes, Thomas E., Farmer, Ben, Cherrington, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191409/
https://ncbi.nlm.nih.gov/pubmed/31990576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00451.2019
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